Challenges and Opportunities for Quantitative Clinical Pharmacology in Cancer Immunotherapy: Something Old, Something New, Something Borrowed, and Something Blue
نویسندگان
چکیده
Cancer immunotherapy (CIT) initiates or enhances the host immune response against cancer. Following decades of development, patients with previously few therapeutic options may now benefit from CIT. Although the quantitative clinical pharmacology (qCP) of previous classes of anticancer drugs has matured during this time, application to CIT may not be straightforward since CIT acts via the immune system. Here we discuss where qCP approaches might best borrow or start anew for CIT.
منابع مشابه
An update on Experimental and Clinical Psychopharmacology: Something old, something new, something borrowed, something green?
In this editorial, the author provides an update on Experimental and Clinical Psychopharmacology in several areas. First, the journal will continue to accept original research reports and full reviews as it has in past years. The author hopes to still receive outstanding manuscripts in the journal's primary areas of strength, such as clinical research on alcohol use and cigarette smoking. The j...
متن کاملPrediction and Classification in Nonlinear Data Analysis: Something Old, Something New, Something Borrowed, Something Blue
Prediction and classification are two very active areas in modern data analysis. In this paper, prediction with nonlinear optimal scaling transformations of the variables is reviewed, and extended to the use of multiple additive components, much in the spirit of statistical learning techniques that are currently popular, among other areas, in data mining. Also, a classification/clustering metho...
متن کامل-
The development and evolution of any system–person, organization–nation depends on how the system succeeds to bridge the gap between what the system knows and what the system does (with the knowledge). We call this the gap between knowing and doing or the knowing-doing gap. If the system does not do what it knows, it will lose out in competition with other systems, its relative performance in...
متن کامل“Something You Do with Your Body”: The Experience and Meaning of Physical Activity from the Perspective of Transnational Youth
Background. The transnational young people’s physical activity participation could intermingle with their ingrained dispositions acquired from their pre-migrating periods, experiences of transnational mobility, new cultural learning, and other migration processes. Objectives. The current study aimed to investigate transnational youth’s physical activity experience using photo-elicitation inte...
متن کاملPeroxisome biogenesis: something old, something new, something borrowed.
Eukaryotic cells are characterized by their varied complement of organelles. One set of membrane-bound, usually spherical compartments are commonly grouped together under the term peroxisomes. Peroxisomes function in regulating the synthesis and availability of many diverse lipids by harnessing the power of oxidative reactions and contribute to a number of metabolic processes essential for cell...
متن کامل